Can we change markdown for bold to one asterisk (instead of two)?

If you are using the iOS format menu, when selecting “Bold” it runs whatever action you have installed in your Drafts’ action list which is assigned to the ⌘-B keyboard shortcut.

By default, this is the “Markdown Bold” action in the “Markdown” action group. That thread I pointed you to details how you could modify that action to support this…see this reply